Cancer is a complex and heterogenous disease composed by several cell types including fibroblasts, immune cells and vascular and lymphatic endothelial cells. All of these cell types form the tumor microenvironment. The communication between all of those cells favors tumor growth and metastasis spread.
Picture representing the tumor microenvironment (TME). CAF: Cancer associated fibroblasts. EC: Endothelial cells. IC: Immune cells.